DSpace logo

Use este identificador para citar ou linkar para este item: http://repositorioinstitucional.uea.edu.br//handle/riuea/5612
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorLima, Maria Eduarda Lira-
dc.date.available2024-04-02-
dc.date.available2024-04-04T15:01:49Z-
dc.date.issued2024-02-19-
dc.identifier.urihttp://repositorioinstitucional.uea.edu.br//handle/riuea/5612-
dc.description.abstractBothrops venom has toxins that are highly damaging to tissues. During poisoning, local clinical events such as pain, edema, localized bleeding, necrosis and myonecrosis, in addition to the risk of amputations and death. The treatment has been proven Effective in these cases is antivenin. However, low- and middle-income regions still have scarcity of specific treatment, in addition to the limitation of trained professionals for the victim support. The use of a tourniquet as an alternative means of poisoning is frequently used and in the literature it has pointed out the worsening of the accident during its use. In this report we describe four cases of poisoning by Bothrops atrox, recorded in the Brazilian Amazon. All cases occurred in men aged between 20 and 52 years old. The victims were residents of the municipalities of Novo Airão, Itacoatiara, São Sebastião do Rio Cuieiras and Manaus. In all accidents, antivenom was used. Bothrops, with three classified as severe cases and two as moderate. The time of arrival for medical care at the reference hospital for snakebites in the capital, Manaus, ranged from 2 to 18 hours. The hands and legs were the affected areas, possibly related to work activities, similar to other studies involving snakebitespt_BR
dc.languageporpt_BR
dc.publisherUniversidade do Estado do Amazonaspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMordedura de serpentept_BR
dc.subjectTorniquetept_BR
dc.subjectPrimeiros socorrospt_BR
dc.subjectSnake bitept_BR
dc.titleUso de torniquete em acídentes ofídicos na Amazônia Brasileira - série de casospt_BR
dc.title.alternativeUse of tourniquet in snakebites in the Brazilian Amazon - case seriespt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.date.accessioned2024-04-04T15:01:49Z-
dc.contributor.advisor1Carvalho, Érica da Silva-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3325190814999717pt_BR
dc.contributor.referee1Carvalho, Érica da Silva-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/3325190814999717pt_BR
dc.contributor.referee2Machado, Vinicius Azevedo-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/9439187681387352pt_BR
dc.contributor.referee3Monteiro, Angela Xavier-
dc.description.resumoO veneno botrópico possui toxinas altamente danosas aos tecidos. Durante o envenenamento, podem ser observados eventos clínicos locais como dor, edema, sangramentos localizados, necrose e mionecrose, além do risco de amputações e óbito. O tratamento comprovadamente eficaz nos casos é o antiveneno. Porém, regiões de baixa e média renda ainda apresentam escassez de tratamento específico, além da limitação de profissionais capacitados para o suporte das vítimas. O uso de torniquete como meio alternativo nos envenenamentos é frequentemente utilizado e na literatura vem apontando o agravamento do acidente durante seu uso. Neste relato descrevemos quatro casos de envenenamento por Bothrops atrox, registrados na Amazônia brasileira. Todos os casos ocorreram com homens de idade entre 20 e 52 anos. As vítimas eram residentes dos municípios de Novo Airão, Itacoatiara, São Sebastião do Rio Cuieiras e Manaus. Em todos os acidentes, houve o uso de antiveneno botrópico, sendo três classificados como casos graves e dois como moderados. O tempo de chegada ao atendimento médico no hospital de referência para acidentes ofídicos na capital, Manaus, variou de 2 a 18 horas. As mãos e as pernas foram os locais acometidos, possivelmente relacionados a atividades laborais, semelhante em outros estudos envolvendo acidentes ofídicospt_BR
dc.publisher.countryBrasilpt_BR
dc.relation.references1. Gutiérrez JM, Calvete JJ, Habib AG, Harrison RA, Williams DJ, Warrell DA. Snakebite envenoming. Nature Reviews Disease Primers 2017 3:1 [Internet]. 2017 Sep 14 [cited 2023 Feb 23];3(1):1–21. Available from: https://www.nature.com/articles/nrdp201763 2. Gutiérrez JM. Snakebite Envenomation in Central America : Epidemiology, Pathophysiology and Treatment. Handbook of Venoms and Toxins of Reptiles [Internet]. 2021 May 24 [cited 2023 Feb 22];543–58. Available from: https://www.taylorfrancis.com/chapters/edit/10.1201/9780429054204-41/snakebite-envenom ation-central-america-jos%C3%A9-mar%C3%ADa-guti%C3%A9rrez 3. Sant’Ana Malaque CM, Gutiérrez JM. Snakebite Envenomation in Central and South America. Critical Care Toxicology [Internet]. 2015 [cited 2023 Feb 22];1–22. Available from: https://link.springer.com/referenceworkentry/10.1007/978-3-319-20790-2_146-1 4. The Lancet. Snakebite—emerging from the shadows of neglect. The Lancet [Internet]. 2019 Jun 1 [cited 2023 Aug 19];393(10187):2175. Available from: http://www.thelancet.com/article/S0140673619312322/fulltext 5. Resiere D, Monteiro W, Houcke S, Pujo JM, Mathien C, Mayence C, et al. Bothrops Snakebite Envenomings in the Amazon Region. Curr Trop Med Rep. 2020;7(2):48–60. 6. Monteiro WM, de Farias AS, Val F, Neto AVS, Sachett A, Lacerda M, et al. Providing Antivenom Treatment Access to All Brazilian Amazon Indigenous Areas: ‘Every Life has Equal Value.’ Toxins (Basel) [Internet]. 2020 Dec 1 [cited 2022 Jul 24];12(12):772. Available from: /pmc/articles/PMC7762137/ 7. Cristino JS, Salazar GM, Machado VA, Honorato E, Farias AS, Vissoci JRN, et al. A painful journey to antivenom: The therapeutic itinerary of snakebite patients in the Brazilian Amazon (The QUALISnake Study). PLoS Negl Trop Dis [Internet]. 2021 Mar 1 [cited 2022 Jul 18];15(3). Available from: /pmc/articles/PMC7963098/ 8. Basnyat B, Shilpakar O. Snakebite envenoming: a hidden health crisis. Lancet Glob Health [Internet]. 2022 Mar 1 [cited 2023 Feb 23];10(3):e311–2. Available from: http://www.thelancet.com/article/S2214109X22000298/fulltext 9. Jeevagan V, Chang T, Gnanathasan CA. Acute ischemic stroke following Hump-nosed viper envenoming; first authenticated case. Thromb J [Internet]. 2012 Sep 20 [cited 2023 Feb 10];10:21. Available from: /pmc/articles/PMC3502189/ 10. Huang YK, Chen YC, Liu CC, Cheng HC, Tu AT, Chang KC. Cerebral Complications of Snakebite Envenoming: Case Studies. Toxins (Basel) [Internet]. 2022 Jul 1 [cited 2023 Feb 10];14(7):436. Available from: /pmc/articles/PMC9320586/ 11. Pucca MB, Franco MVS, Medeiros JM, Oliveira IS, Ahmadi S, Cerni FA, et al. Chronic kidney failure following lancehead bite envenoming: a clinical report from the Amazon region. Journal of Venomous Animals and Toxins including Tropical Diseases [Internet]. 2020 Dec 14 [cited 2023 Aug 19];26:e20200083. Available from: https://www.scielo.br/j/jvatitd/a/kp3sWvkHTgkfVnchXY6QN5B/?lang=en 12. Moretto Del-Rei TH, Sousa LF, Rocha MMT, Freitas-de-Sousa LA, Travaglia-Cardoso SR, Grego K, et al. Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings. Toxicon [Internet]. 2019;164(January):61–70. Available from: https://doi.org/10.1016/j.toxicon.2019.04.001 13. Larréché S, Chippaux JP, Chevillard L, Mathé S, Résière D, Siguret V, et al. Bleeding and thrombosis: Insights into pathophysiology of bothrops venom-related hemostasis disorders. Int J Mol Sci. 2021;22(17). 14. Núñez V, Cid P, Sanz L, De La Torre P, Angulo Y, Lomonte B, et al. Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism. J Proteomics [Internet]. 2009;73(1):57–78. Available from: http://dx.doi.org/10.1016/j.jprot.2009.07.013 15. Cezarette GN, Sartim MA, Sampaio S V. Inflammation and coagulation crosstalk induced by BJcuL, a galactose-binding lectin isolated from Bothrops jararacussu snake venom. Int J Biol Macromol [Internet]. 2020;144:296–304. Available from: https://doi.org/10.1016/j.ijbiomac.2019.12.015 16. Baldo C, Jamora C, Yamanouye N, Zorn TM, Moura-da-Silva AM. Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: Tissue distribution and in Situ hydrolysis. PLoS Negl Trop Dis. 2010;4(6). 17. Tashima AK, Zelanis A, Kitano ES, Ianzer D, Melo RL, Rioli V, et al. Peptidomics of Three Bothrops Snake Venoms: Insights Into the Molecular Diversification of Proteomes and Peptidomes. Mol Cell Proteomics [Internet]. 2012 Nov [cited 2022 Aug 9];11(11):1245. Available from: /pmc/articles/PMC3494202/ 18. de Souza CA, Kayano AM, Setúbal SS, Pontes AS, Furtado JL, Kwasniewski FH, et al. Local and systemic biochemical alterations induced by Bothrops atrox snake venom in mice. J Venom Res [Internet]. 2012;3:28–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23487552%0Ahttp://www.pubmedcentral.nih.gov/artic lerender.fcgi?artid=PMC3595125 19. Cavalcante JS, Brito IM da C, De Oliveira LA, De Barros LC, Almeida C, Rossini BC, et al. Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation. Toxins (Basel) [Internet]. 2022 Sep 1 [cited 2023 Aug 19];14(9). Available from: /pmc/articles/PMC9503785/ 20. Gutiérrez JM, Escalante T, Rucavado A, Herrera C. Hemorrhage caused by snake venom metalloproteinases: A journey of discovery and understanding. Toxins (Basel). 2016;8(4). 21. Vikrant S, Parashar A. Case report: Snake bite-induced acute kidney injury: Report of a successful outcome during pregnancy. American Journal of Tropical Medicine and Hygiene. 2017;96(4):885–6. 22. Gutiérrez JM, Rucavado A. Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage. Biochimie [Internet]. 2000 [cited 2023 Aug 19];82(9–10):841–50. Available from: https://pubmed.ncbi.nlm.nih.gov/11086214/ 23. De Almeida MT, Freitas-De-Sousa LA, Colombini M, Gimenes SNC, Kitano ES, Faquim-Mauro EL, et al. Inflammatory Reaction Induced by Two Metalloproteinases Isolated from Bothrops atrox Venom and by Fragments Generated from the Hydrolysis of Basement Membrane Components. Toxins (Basel) [Internet]. 2020 [cited 2023 Aug 21];12(2):96. Available from: /pmc/articles/PMC7076977/ 24. Jayawardana S, Arambepola C, Chang T, Gnanathasan A. Long-term health complications following snake envenoming. J Multidiscip Healthc [Internet]. 2018 Jun 26 [cited 2023 Aug 21];11:279. Available from: /pmc/articles/PMC6027691/ 25. Bhaumik S, Kallakuri S, Kaur A, Devarapalli S, Daniel M. Mental health conditions after snakebite: a scoping review. BMJ Glob Health [Internet]. 2020 Nov 30 [cited 2023 Aug 21];5(11). Available from: https://pubmed.ncbi.nlm.nih.gov/33257419/ 26. Monteiro WM, de Farias AS, Val F, Neto AVS, Sachett A, Lacerda M, et al. Providing Antivenom Treatment Access to All Brazilian Amazon Indigenous Areas: ‘Every Life has Equal Value.’ Toxins 2020, Vol 12, Page 772 [Internet]. 2020 Dec 5 [cited 2022 Nov 8];12(12):772. Available from: https://www.mdpi.com/2072-6651/12/12/772/htm 27. Maciel Salazar GK, Saturnino Cristino J, Vilhena Silva-Neto A, Seabra Farias A, Alcântara JA, Azevedo Machado V, et al. Snakebites in “Invisible Populations”: A cross-sectional survey in riverine populations in the remote western Brazilian Amazon. PLoS Negl Trop Dis. 2021;15(9):e0009758. 28. Fry BG. Snakebite: When the Human Touch Becomes a Bad Touch. Toxins (Basel) [Internet]. 2018 Apr 21 [cited 2023 Aug 21];10(4):170. Available from: /pmc/articles/PMC5923336/ 29. Tun-Pe, Tin-Nu-Swe, Myint-Lwin, Warrell DA, Than-Win. The efficacy of tourniquets as a first-aid measure for Russell’s viper bites in Burma. Trans R Soc Trop Med Hyg [Internet]. 1987 [cited 2023 Aug 21];81(3):403–5. Available from: https://pubmed.ncbi.nlm.nih.gov/2961108/ 30. Amaral CFS, Campolina D, Dias MB, Bueno CM, Rezende NA. Tourniquet ineffectiveness to reduce the severity of envenoming after Crotalus durissus snake bite in Belo Horizonte, Minas Gerais, Brazil. Toxicon [Internet]. 1998 May 15 [cited 2023 Aug 21];36(5):805–8. Available from: https://pubmed.ncbi.nlm.nih.gov/9655642/ 31. Mehta SR, Sashindran VK. Clinical Features And Management Of Snake Bite. Med J Armed Forces India [Internet]. 2002 [cited 2023 Aug 21];58(3):247. Available from: /pmc/articles/PMC4925324/ 32. Otero R, Gutiérrez J, Beatriz Mesa M, Duque E, Rodríguez O, Luis Arango J, et al. Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital. Toxicon. 2002 Aug 1;40(8):1107–14. 33. Campos Borges C, Sadahiro M, dos Santos MC. Aspectos epidemiológicos e clínicos dos acidentes ofídicos ocorridos nos municípios do Estado do Amazonas. Rev Soc Bras Med Trop [Internet]. 1999 [cited 2023 Aug 21];32(6):637–46. Available from: https://www.scielo.br/j/rsbmt/a/WZXDw6YPhpjzxf4wggLqnFF/?lang=pt 34. Ribeiro LA, Jorge MT, Lebrão ML. Prognostic factors for local necrosis in Bothrops jararaca (Brazilian pit viper) bites. Trans R Soc Trop Med Hyg. 2001;95(6):630–4. 35. Mahmood MA, Halliday D, Cumming R, Thwin KT, Myitzu M, White J, et al. Inadequate knowledge about snakebite envenoming symptoms and application of harmful first aid methods in the community in high snakebite incidence areas of Myanmar. PLoS Negl Trop Dis [Internet]. 2019 Feb 1 [cited 2023 Aug 21];13(2). Available from: https://pubmed.ncbi.nlm.nih.gov/30768596/ 36. Guidelines for the management of snake-bites [Internet]. [cited 2023 Aug 21]. Available from: https://apps.who.int/iris/handle/10665/204464 37. Avau B, Borra V, Vandekerckhove P, De Buck E. The Treatment of Snake Bites in a First Aid Setting: A Systematic Review. PLoS Negl Trop Dis [Internet]. 2016 Oct 17 [cited 2023 Aug 21];10(10). Available from: https://pubmed.ncbi.nlm.nih.gov/27749906/ 38. Amaral CFS, Campolina D, Dias MB, Bueno CM, Rezende NA. Tourniquet ineffectiveness to reduce the severity of envenoming after Crotalus durissus snake bite in Belo Horizonte, Minas Gerais, Brazil. Toxicon. 1998 May 15;36(5):805–8. 39. Bush SP, Kinlaw SB. Management of a Pediatric Snake Envenomation After Presentation With a Tight Tourniquet. Wilderness Environ Med. 2015 Sep 1;26(3):355–8. 40. Mahmood MA, Halliday D, Cumming R, Thwin KT, Myitzu M, White J, et al. Inadequate knowledge about snakebite envenoming symptoms and application of harmful first aid methods in the community in high snakebite incidence areas of Myanmar. PLoS Negl Trop Dis [Internet]. 2019 Feb 1 [cited 2023 Aug 21];13(2):e0007171. Available from: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007171 41. Ait Essi F, Benhima MA, Abkari I, Najeb Y, Latifi M, Khallouki M, et al. L’amputation des doigts par morsure de serpent : à propos de trois cas. Chir Main. 2013 Apr 1;32(2):92–5. 42. Watt G, Padre L, Tuazon ML, Theakston RDG, Laughlin LW. Tourniquet application after cobra bite: delay in the onset of neurotoxicity and the dangers of sudden release. Am J Trop Med Hyg [Internet]. 1988 [cited 2023 Aug 21];38(3):618–22. Available from: https://pubmed.ncbi.nlm.nih.gov/3275141/ 43. Moreira L, Gutiérrez J, Borkow G, Ovadia M. Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo). Exp Mol Pathol. 1992 Oct 1;57(2):124–33. 44. França FO de S, Barbaro KC, Fan HW, Cardoso JLC, Sano-Martins IS, Tomy SC, et al. Envenoming by Bothrops jararaca in Brazil: association between venom antigenaemia and severity at admission to hospital. Trans R Soc Trop Med Hyg [Internet]. 2003 May [cited 2023 Aug 21];97(3):312–7. Available from: https://pubmed.ncbi.nlm.nih.gov/15228251/ 45. Wang W, Chen QF, Yin RX, Zhu JJ, Li Q Bin, Chang HH, et al. Clinical features and treatment experience: a review of 292 Chinese cobra snakebites. Environ Toxicol Pharmacol [Internet]. 2014 Mar [cited 2023 Aug 21];37(2):648–55. Available from: https://pubmed.ncbi.nlm.nih.gov/24577231/ 46. Michael GC, Thacher TD, Shehu MIL. The effect of pre-hospital care for venomous snake bite on outcome in Nigeria. Trans R Soc Trop Med Hyg [Internet]. 2011 Feb [cited 2023 Aug 21];105(2):95–101. Available from: https://pubmed.ncbi.nlm.nih.gov/21035155/ 47. Madaki J, Mandong B, Obilom R. Pattern of First-Aid Measures Used by Snake-bite Patients and Clinical Outcome at Zamko Comprehensive Health Centre; Langtang; Plateau State. Nigerian Medical Practitioner. 2005;10–3. 48. Michael GC, Bala AA, Mohammed M. Snakebite knowledge assessment and training of healthcare professionals in Asia, Africa, and the Middle East: A review. Toxicon X. 2022 Dec 1;16:100142pt_BR
dc.publisher.initialsUEApt_BR
Aparece nas coleções:ESA - Trabalho de Conclusão de Curso Graduação

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
Uso de torniquete em acídentes ofídicos na Amazônia Brasileira - série de casos.pdf6,72 MBAdobe PDFVisualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.