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dc.contributor.authorRodrigues, Keila Thais Passos Martins-
dc.date.available2022-08-08-
dc.date.available2022-08-11T16:47:57Z-
dc.date.issued2020-08-20-
dc.identifier.urihttp://repositorioinstitucional.uea.edu.br//handle/riuea/4113-
dc.description.abstractAn analysis of the umbilical cord blood count has the advantage of avoiding vascular puncture in the newborn, thus reducing the risk of infection. It is known that maternal hematological and biochemical parameters may differ when compared to their specific newborns. Therefore, it is important to assess the impact of maternal laboratory and sociodemographic data on newborns. Objective: To characterize laboratory data of postpartum women and umbilical cord blood of full-term and premature newborns and compare them to sociodemographic variables and laboratory data of postpartum women. Methodology: A cross-sectional observational study was carried out in 467 puerperal women, and their newborns, attended at the Maternidades Pública Alvorada and Instituto da Mulher Dona Lindu in the city of Manaus, from June 2017 to March 2019. Data sociodemographic clinics were obtained through a questionnaire and access to the medical records of the mothers. Hematological and biochemical data were acquired through analyzes performed on the peripheral venous blood of puerperal women and the umbilical cord of newborns. Results: As for the puerperal women, 379 (81.1%) declared themselves brown, 64.8% were attending or had completed high school, most were married (76.4%) and the average age was 20, 1 ± 6.4. Normal delivery occurred in 53.5% of births. Triglyceride levels were proportionate to advancing gestational age at delivery. The absolute number of leukocytes was higher in those puerperal women between 12 and 15 years old and male newborns had a high elevated transferrin, while female newborns had a high MCV and HCM. Conclusion: Our results show that the status of iron and hemoglobin may not be associated with each other when it appears in umbilical cord blood. Furthermore, we observed important differences in hematological parameters when associated with spontaneous abortion. We understand that the knowledge of the hematological and biochemical profile of pregnant women and their respective newborns can contribute to minimize neonatal morbidity and mortality, as well as generate subsidies for further studies in the context of qualifying prenatal carept_BR
dc.languageporpt_BR
dc.publisherUniversidade do Estado do Amazonaspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPuérperapt_BR
dc.subjectRecém-nascidopt_BR
dc.subjectManauspt_BR
dc.titleCaracterização hematológica e bioquímica de puérperas - impactos no filho recém-nascidopt_BR
dc.title.alternativeHematological and biochemical characterization of postpartum women - impacts on the newborn childpt_BR
dc.typeDissertaçãopt_BR
dc.date.accessioned2022-08-11T16:47:57Z-
dc.contributor.advisor1Moura Neto, José Pereira de-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6749773067557179pt_BR
dc.contributor.referee1Tarragô, Andrea Monteiro-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/4644326589690231pt_BR
dc.contributor.referee2Esashiba, Myuki Alfaia-
dc.contributor.referee3Matsuura, Miharu Magnoria-
dc.creator.Latteshttp://lattes.cnpq.br/2919274662315373 Endereçopt_BR
dc.description.resumoA análise do hemograma do cordão umbilical tem vantagem de evitar punção vascular no recém-nascido, diminuindo, assim o risco de infecção. Sabe-se que parâmetros hematológicos e bioquímicos maternos podem apresentar diferenças significativas quando comparados aos seus respectivos recém-nascidos. Logo, é importante avaliar qual o impacto dos dados laboratoriais e sociodemográficos maternos aos recém-nascidos. Objetivo: Caracterizar dados laboratoriais de puérperas e sangue de cordão umbilical de recém-nascidos a termo e prematuros e compará-los às variáveis sociodemográficas e dados laboratoriais das puérperas. Metodologia: Foi realizado um estudo observacional descritivo transversal em 467 puérperas, e seus respectivos recém- nascidos, atendidas nas Maternidades Públicas Alvorada e Instituto da Mulher Dona Lindu da cidade de Manaus, durante o período de junho de 2017 a Março de 2019. Os dados clínicos sociodemográficos foram obtidos através de questionário e acesso ao prontuário das puérperas. Os dados hematológicos e bioquímicos foram adquiridos por meio de análises realizadas no sangue venoso periférico de puérperas e cordão umbilical do recém-nascidos. Resultados: Quanto às puérperas, declararam-se pardas 379 (81,1%), estava cursando ou havia concluído o ensino médio 64,8%, a maioria era casada (76,4%) e a média de idade foi de 20,1±6,4. O parto normal ocorreu em 53,5% dos nascimentos. Os níveis de triglicerídeos foram proporcionais ao avanço da idade gestacional no momento do parto. O número absoluto de leucócitos esteve maior naquelas puérperas entre 12 e 15 anos e os recém-nascidos do sexo masculino apresentaram elevada concentração de transferrina, enquanto recém-nascidos do sexo feminino elevação do VCM e HCM. Conclusão: Nossos resultados mostram que o status de ferro e hemoglobina podem não haver associação entre si quando analisados no sangue do cordão umbilical. E, ainda, observamos diferenças significativas nos parâmetros hematológicos quando associados ao aborto espontâneo. Entendemos que o conhecimento do perfil hematológico e bioquímico das gestantes e de seus respectivos recém-nascidos pode contribuir para minimizar a morbimortalidade neonatal, assim como gerar subsídios para estudos posteriores no âmbito da qualificação da assistência pré-natalpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.programPPGH -PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS APLICADAS À HEMATOLOGIApt_BR
dc.relation.references1 Demetrio F (2010) Pirâmide alimentar para gestantes eutróficas de 19 a 30 anos. Rev Nutr. 23(5):763–778. 2 Koletzko B, Godfrey K, M, Poston L, Szajewska H, et al. (2019) Nutrition During Pregnancy, Lactation and Early Childhood and its Implications for Maternal and Long-Term Child Health: The Early Nutrition Project Recommendations. Ann Nutr Metab74:93-106. doi: 10.1159/000496471 3 Forbes GB. 1978. The Epidemiology of Prematurity. Am J Dis Child;132(5):535. 4. Wojtyla C, Bilinski P, Paprzycki P et al. 2011. Haematological parameters in postpartum women and their babies in Poland: comparison of urban and rural areas. Ann Agr Env Med 18(2);380-5. 5 Sá AS, Willner E, Pereira TAD et al. 2015. Anemia in pregnancy: impact on weight and in the development of anemia in newborn. Nutr Hosp. 32(5):2071-2079. 6 Rehu M, Punnonen K, Ostland V et al. 2010. Maternal serum hepcidin is low at term and independent of cord blood iron status. EUR. J. Haematol. 85 : 345–352. 7 Steer RA, Scholl TO, Hediger ML, Fischer RL. 1992. Self-reported depression and negative pregnancy outcomes. J Clin Epidemiol.45(10):1093-1099. 8 Ballard O, Morrow AL. 2013. Human Milk Composition: Nutrients and bioactive factors. Pediatr Clin North Am. 60(1):49-74. 9 Oliveira LP, Assis AM, Silva MC et al. 2009. Fatores associados a excesso de peso e concentração de gordura abdominal em adultos na cidade de Salvador, Bahia, Brasil. Cad Saúde Pública; 25(3): 570-82. 10 Sichieri R, Moura EC. 2009. Análise multinível das variações do índice de massa corporal entre adultos, Brasil, 2006. Rev Saúde Pública; 43(2): 90-7. 11 Gravena AAF, Paula MG, Marcon SS et al. 2013. Maternal age and factors associated with perinatal outcomes. Acta Paul Enferm. 26(2):130-5. 33 12 12Freeman AM, Rai M, Morando DW. 2020. Anemia Screening.In: StatPearls Treasure Island (FL): 13 Organização Mundial da Saúde (OMS) A prevalência global de anemia em 2011. Genebra: Organização Mundial da Saúde; 2015. 14 Burgoon JM, Selhub J, Nadeau M et al. 2002. Investigation of the effect so folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology, 65(5): 219-227. 15 Pereira, MU & Solé, D. 2015. Deficiência de vitamina D na gravidez e seu impacto sobre o feto, o recém-nascido e na infância. Ver Paul Pediatr. 33(1):104-113. 16 Neves P, Saunders C, Barros D et al .2015. Suplementação com vitamina A em gestantes e puérperas brasileiras: uma revisão sistemática. 2015. ver Bras Epidemio. 18(4): 824-836. 17 Ministério da Saúde. 2016. Departamento de Atenção básica, Relatório Técnico Final de Pesquisa Nacional para avaliação do impacto da iodação do sal (2016). Disponível em: http://189.28.128.100/dab/docs/portaldab/documentos/pnaisal_relatorio_final.pdf. Acessed 02 Jul 2020. 18 Timilsina S, Karki S, Gautam A, Bhusal P, Paudel G, Sharma D. 2018. Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study. BMC Pregnancy Childbirth. 2018;18(1):70. 19 Evans E, Farrant P, Gowland M, McNay MB, Richards B. 1990. Clinical applications of ultrasonic fetal measurements. London: British Medical Ultrasound Society/British Institute of Radiology. 20 Smith GCS, Wood AM, Pell JP, White IR, Crossley JA, Dobbie R. 2004. Second-trimester maternal serum levels of alpha-fetoprotein and the subsequent risk of sudden infant death syndrome. N Engl J Med. 351:978–86. 34 21 Martin JA, Kochanek KD, Strobino DM, Guyer B, MacDorman MF. 2005. Annual summary of vital statistics–2003. Pediatrics 115: 619–34. 23 Domingues RM, Dias MA, Nakamura-Pereira M, et al. 2014. Process of decision-making regarding the mode of birth in Brazil: from the initial preference of women to the final mode of birth. Cad Saude Publica. 30 Suppl 1:S1-S16. 24 Kost K and Henshaw S, U.S. 2014. Teenage Pregnancies, Births and Abortions, 2010: National and State Trends by Age, Race and Ethnicity, New York: Guttmacher Institute. 25 Wilkinson P, French R, Kane R, et al. 2006. Teenage conceptions, abortions, and births in England, 1994-2003, and the national teenage pregnancy strategy. Lancet. 368(9550):1879- 1886. 26 Humby P.2013. An analysis of under 18 conceptions and their links to measures of deprivation, England and Wales, 2008-10. Office for National Statistics, London, 27 Novaes ES, Oliveira RR, Melo EC, Varela PLR, Mathias TAF. Perfil obstétrico de usuários do sistema público de saúde após implantação da rede mãe do estado do Paraná- Brasil. Cienc Cuid Saúde. 2015; 14 (4): 1436-144. 28 Rowińska J, Małyszko J, Wieliczko M. 2015. Urinary tract infections in pregnancy: old and new unresolved diagnostic and therapeutic problems. Arch Med Sci.;11(1):67-77. 29 Georgieff MK, Schmidt RL, Mills MM, Radmer WJ, Widness JA. Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration. Am J Physiol. 1992;262(3 Pt 2):R485-R491. 30 Nicolaides C, Panaitescu, A. Syngelaki, N. Prodan, R. Akolekar and K. H. 2017 Chronic hypertension and adverse pregnancy outcome: a cohort study. A. M. Ultrasound Obstet Gynecol 50: 228–235. 35 31 Fichorova RN, Beatty N, Sassi RR, et al. 2015. Systemic inflammation in the extremely low gestational age newborn following maternal genitourinary infections. Am J Reprod Immunol. 73(2):162-174. 32 Ozyürek E, Cetintas S, Ceylan T, Ogüs E, Haberal A, Gürakan B. 2006. Complete blood count parameters for healthy, small‐for‐gestational‐age, full‐term newborns. Clin Lab Haematol. 28 : 97–104. 33 Hsieh WS, Wu JH, Chou HC, Chen PC, Jeng SF, Chen CY, Tsao PN, Hsieh CJ, Huang HM. 2009. Impact of delivery mode and gestational age on haematological parameters in taiwanese preterm infants. Journal of Paediatrics and Child Health. 45:332-336. 34 Qaiser DH, Sandila MP, Omair A, Ghori GM. 2013. Correlation of routine haematological parameters between normal maternal blood and the cord blood of healthy newborns in selected hospitals of Karachi. J Coll Physicians Surg Pak. 23(2):128-131 35 Delaney KM, Guillet R, Fleming RE, et al. 2019 Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples. J Nutr. 149(3):406-415. 36 Christensen RD, Henry E, Jopling J, Wiedmeier SE. 2009. The CBC: reference ranges for neonates. Semin Perinatol. 33(1):3-11. 37 Ghaemi S, Najafi R,Kelishadi R:2014 Cord blood lipoprotein profile in term, preterm, and late preterm newborns. J Res Med Sci 19: 1038–1040 38 McCloskey, K., De Livera, A. M., Collier, F., et al. 2018. Gestational Age and the Cord Blood Lipidomic Profile in Late Preterm and Term Infants. Neonatology, 215–222. 39 Ma DC, Sun YH, Chang KZ, Zuo W. 1996 Developmental change of megakaryocyte maturation and DNA ploidy in human fetus. Eur J Haematol. 57(2):121-127. 36 40 Murray NA, Watts TL, Roberts IA. 1998. Endogenous thrombopoietin levels and effect of recombinant human thrombopoietin on megakaryocyte precursors in term and preterm babies. Pediatr Res. 43(1):148–151. 41 Watts TL, Murray NA, Roberts IA. 1999. Thrombopoietin has a primary role in the regulation of platelet production in preterm babies. Pediatr. Res. 46(1):28-32. 42 Liu ZJ, Italiano J Jr, Ferrer-Marin F, Gutti R, Bailey M, Poterjoy B, Rimsza L, Sola-Visner M. 2011. Developmental differences in megakaryocytopoiesis are associated with up- regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood.117(15):4106-4117. 43 Henry E, Christensen RD. 2015. Reference Intervals in Neonatal Hematology. Clin Perinatol. 42(3):483-497. 44 Rolim, Anna Carolina Boni et al. 2019 Blood Cells Profile In Umbilical Cord Of Late Preterm And Term Newborns. Rev. paul. pediatr. [online]. vol.37, n.3, pp.264-274. Epub June 19, 2019. ISSN 1984-0462. 45 Aslinia F, Mazza JJ, Yale SH. 2006. Megaloblastic anemia and other causes of macrocytosis. Clin Med Res 4(3): 236–241. 46 Glasser L, Sutton N, Schmeling M, Machan JT. 2015. A comprehensive study of umbilical cord blood cell developmental changes and reference ranges by gestation, gender and mode of delivery. J Perinatol. 35(7):469-475. 47 Machado Jde B, Plínio Filho VM, Petersen GO, Chatkin JM. 2011. Quantitative effects of tobacco smoking exposure on the maternal-fetal circulation. BMC Pregnancy Childbirth. ;11:24. 48 Bili H, Mamopoulos M, Tsantali C, et al.1996. Elevated umbilical erythropoietin levels during labor in newborns of smoking mothers. Am J Perinatol.;13(2):85-87. 37 49 Pateva IB, Kerling EH, Reddy M, Chen D, Carlson SE, Tancabelic J. 2015 Effect of Maternal Cigarette Smoking on Newborn Iron Stores. Clin Res Trials. 1(1):4-7pt_BR
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