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http://repositorioinstitucional.uea.edu.br//handle/riuea/3661Registro completo de metadados
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Bandeira, Izabel Correa | - |
| dc.date.available | 2022-01-12 | - |
| dc.date.available | 2022-01-12T12:16:57Z | - |
| dc.date.issued | 2021-07-12 | - |
| dc.identifier.citation | BANDEIRA, Izabel Correa. Análise de genes parálogos do hormônio liberador de gonadotrofinas (GnRH) e seu receptor (GnRHR), envolvidos no processo reprodutivo do tambaqui Colossoma macropomum. 2021. 40 f. TCC (Graduação em Ciências Biológicas) - Universidade do Estado do Amazonas, Manaus. | pt_BR |
| dc.identifier.uri | http://repositorioinstitucional.uea.edu.br//handle/riuea/3661 | - |
| dc.description.abstract | The gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor genes are the most common molecular signal used by the brain to regulate gonadotropin synthesis, plays an important role in almost all vertebrates reproduction. The tambaqui showed three parallel lines of GnRH (cmgnrh1, cmgnrh2 and cmgnrh3) and your receptor GnRHR (cmgnrhr1c, cmgnrhr1ca and cmgnrhr2b), wherein the three binders genes encoding the forms sbGnRH, cGnRH-II and sGnRH. Analysis with gonadal transcripts of the cmgnrh3 gene (sGnRH) reveal a frameshift-like mutation, originating a premature stop codon at the beginning of exon2, which contains the information for the production of the sGnRH peptide. Despite this fact indicating a possible pseudogenization, the gene exhibits high levels of transcription in the olfactory bulb of males and females, presenting differentiated expression in ovaries at the beginning of puberty (data not yet published), suggesting a likely functional role to be investigated, whereas no study so far has analyzed the functioning of this system in the Colossoma macropomum species. Keywords: Colossoma macropomum; Tambaqui; GnRH; frameshift. | pt_BR |
| dc.language | por | pt_BR |
| dc.publisher | Universidade do Estado do Amazonas | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Colossoma macropomum | pt_BR |
| dc.subject | Tambaqui | pt_BR |
| dc.subject | GnRH | pt_BR |
| dc.subject | Frameshift | pt_BR |
| dc.title | Análise de genes parálogos do hormônio liberador de gonadotrofinas (GnRH) e seu receptor (GnRHR), envolvidos no processo reprodutivo do tambaqui Colossoma macropomum | pt_BR |
| dc.title.alternative | Analysis of paralog genes of gonadotropin releasing hormone (GnRH) and its receptor (GnRHR), involved in the reproductive process of tambaqui Colossoma macropomum | pt_BR |
| dc.type | Trabalho de Conclusão de Curso | pt_BR |
| dc.date.accessioned | 2022-01-12T12:16:57Z | - |
| dc.contributor.advisor-co1 | Silva, Gilvan Ferreira da | - |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/1000535673605322 | pt_BR |
| dc.contributor.advisor1 | Bührnheim, Cristina Motta | - |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/6552256507605884 | pt_BR |
| dc.contributor.referee1 | Batista, Ieda Hortêncio | - |
| dc.contributor.referee2 | Buhrnheim, Cristina Mota | - |
| dc.contributor.referee3 | O’Sullivan, Fernanda Loureiro Almeida | - |
| dc.creator.Lattes | http://lattes.cnpq.br/2437066147679329 | pt_BR |
| dc.description.resumo | Os genes do hormônio liberador de gonadotrofinas (GnRH) e seu receptor (GnRHR) consistem na sinalização molecular mais utilizada pelo cérebro para regular a síntese e liberação de gonadotrofinas, sendo crucial na reprodução de muitos vertebrados. O tambaqui apresenta três genes parálogos para o GnRH (cmgnrh1, cmgnrh2 e cmgnrh3) e seu receptor (cmgnrhr1c, cmgnrhr1ca e cmgnrhr2b), em que os genes ligantes codificam as formas sbGnRH, cGnRH-II e sGnRH. Os transcritos gonadais do gene cmgnrh3 (sGnRH) apresentam frameshift com códon de parada prematuro. E, embora este fato indique um processo de pseudogenização, o gene exibe níveis elevados de transcrição em ovários que iniciam a puberdade e no bulbo olfatório de ambos os sexos (dados ainda não publicados), sugerindo um provável papel funcional a ser investigado, visto que, até então nenhum estudo elucidou para o tambaqui o comportamento do sistema GnRH em ambiente de cativeiro, informações que fundamentarão novas estratégias para a manipulação e melhoramento da desova nesta espécie. Palavras-chaves: Colossoma macropomum; Tambaqui; GnRH; frameshift | pt_BR |
| dc.publisher.country | Brasil | pt_BR |
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| dc.subject.cnpq | Ciências Biológicas | pt_BR |
| dc.publisher.initials | UEA | pt_BR |
| Aparece nas coleções: | ENS - Trabalho de Conclusão de Curso de Graduação | |
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